Despite the availability of effective psychopharmacologic and psychotherapeutic treatments for anxiety disorders, many patients continue to experience symptoms. Several real-world challenges complicate treatment, including limited access to effective psychotherapy, particularly in low-income and rural areas.
Additionally, comorbid conditions such as substance use disorders can complicate treatment, often reducing its effectiveness. Medications used to treat anxiety can also cause side effects like palpitations, jitteriness, nausea, drowsiness, and insomnia, which can be difficult for patients to manage.
Treatment resistance is a significant concern, with only 45% to 65% of patients responding to initial treatment with either psychotherapy or pharmacotherapy, and remission rates are even lower, ranging from approximately 40% to 51%. These challenges emphasize the urgent need for novel therapeutics to lessen the impact of anxiety disorders on individuals and society.